5-Amino 1-MQ 50mg

El Toro 5 Amino 1-MQ

is a small molecule research compound that acts as a highly selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in the regulation of cellular methylation and NAD⁺ metabolism. NNMT catalyses the methylation of nicotinamide (vitamin B3), diverting it away from the NAD⁺ salvage pathway and thereby limiting NAD⁺ availability within the cell. Elevated NNMT activity has been linked to metabolic dysfunction, obesity, insulin resistance, certain cancers, and age-related decline in mitochondrial function.

By inhibiting NNMT, 5-Amino-1MQ helps to preserve intracellular nicotinamide, allowing for continued recycling into NAD⁺ via the salvage pathway. NAD⁺ is a central cofactor for mitochondrial oxidative phosphorylation and sirtuin activation, and its maintenance is essential for healthy energy metabolism, DNA repair, and cellular longevity. Restoration of NAD⁺ balance through NNMT inhibition has made 5-Amino-1MQ a molecule of significant interest across multiple areas of research.

Each vial contains 50mg of lyophilised 5-Amino 1-MQ, produced under ISO-certified laboratory conditions to maintain precision, purity, and reproducibility.

Chemical Background / Research Profile

• Synonyms: 5-Amino-1MQ, NNMT inhibitor 5-Amino-1MQ

• Molecular formula: C₁₀H₁₁N₂⁺

• IUPAC Condensed Amino Acid Sequence: N/A

• Molecular Weight: Approximately 159.21g/mol

• CAS Number: 42464-96-0

Purity and Quality Assurance

El Toro ensures each batch of 5-Amino 1-MQ meets a minimum purity standard of ≥ 98 %, confirmed by HPLC and mass spectrometry (MS). Manufacturing is carried out in ISO-accredited laboratories following Good Manufacturing Practice (GMP) and Good Laboratory Practice (GLP).
Each vial is sealed under sterile, tamper-evident conditions and supplied with a Certificate of Analysis (CoA) detailing batch number, analytical results, and expiry date to guarantee full traceability.

Laboratory Handling and Storage

Store at 2–8 °C in a cool, dry environment, protected from direct sunlight. For long-term preservation, refrigeration or freezing at –20 °C is recommended.
Before opening, allow the vial to reach ambient temperature to prevent condensation. Reconstitute using sterile bacteriostatic water or another laboratory-approved diluent under aseptic conditions.
Avoid repeated freeze–thaw cycles and dispose of any remaining solution according to institutional biosafety procedures.

Laboratory personnel must wear appropriate PPE, including gloves, protective eyewear, and lab coats, when handling peptide materials.

Safety, Compliance and Restrictions

5 Amino 1-MQ is not approved for human or veterinary use, not a pharmaceutical, and not intended for therapeutic, diagnostic, or cosmetic application. It is supplied strictly for laboratory research purposes only.

El Toro operates in full compliance with MHRA, REACH, and COSHH regulations governing non-medicinal research chemicals. Researchers must handle all materials within authorised facilities and adhere to local biosafety guidelines.

By maintaining exceptional quality standards, transparent documentation, and strict regulatory adherence, El Toro provides researchers with consistent, verifiable materials that support the safe and reproducible study of peptide biology and molecular mechanisms.